He is of one quarter Cuban and three quarters Puerto Rican descent.
He has appeared in commercials, including one for Coca-Cola. His first film appearance was as an extra in The X-Files. He later appeared on Brooklyn South, Law & Order, Felicity, Roswell (alongside Brendan Fehr, with whom he would reunite in CSI: Miami) and NYPD Blue. He has appeared in a number of music videos, including Jennifer Lopez's 1999 video, "If You Had My Love", Busta Rhymes' "Respect My Conglomerate", Lionel Richie's "I Call it Love", opposite Nicole Richie, Melanie Fiona's "It Kills Me", and 50 Cent's "Many Men", alongside Rory Cochrane. He was also a participant in the pro-Obama video, "Yes We Can."
He was also one of the main characters in CSI: Miami and starred in the 2009 Tyler Perry movie I Can Do Bad All By Myself as Sandino, alongside Taraji P. Henson. Rodriguez also co-starred in a smaller film called Love and Debate. He played Bobby, Hilda's love interest in season 4 of Ugly Betty. He balances his life between NY and LA, and has a third residence in Puerto Rico.
Look at that cute booty... Wow!